GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs11723261 | 1 | rs77078697 | chr4:252048 | ZNF718 | chr4:53272-156488:+ | 0.29 | 4.06 | 5.94E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs6951245 | 1 | rs77083167 | chr7:1071823 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7714584 | 1 | rs7709388 | chr5:150246539 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.77 | 1.66E-8 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7709464 | chr5:150269441 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7709650 | chr5:150246685 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.83 | 1.2E-8 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7714415 | chr5:150270292 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 6.1 | 2.61E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7714584 | chr5:150270420 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.28 | 9.26E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7715981 | chr5:150258107 | LOC134466 | chr5:150310000-150326146:- | 0.49 | 6.4 | 4.65E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7716903 | chr5:150258574 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.22 | 1.33E-9 | Crohn's disease |
| BLCA | cis | rs80285556 | 1 | rs77187281 | chr19:50507667 | SIGLEC16 | chr19:50472912-50479075:+ | 0.59 | 5.55 | 5.41E-8 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs11723261 | 1 | rs77234191 | chr4:258294 | ZNF718 | chr4:53272-156488:+ | 0.33 | 4.42 | 1.27E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs7714584 | 1 | rs7724036 | chr5:150284808 | LOC134466 | chr5:150310000-150326146:- | -0.46 | -6.11 | 2.42E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7724558 | chr5:150328866 | LOC134466 | chr5:150310000-150326146:- | 0.58 | 6.36 | 5.92E-10 | Crohn's disease |
| BLCA | cis | rs7726839 | 1 | rs7726839 | chr5:618586 | SLC9A3 | chr5:473334-524549:- | 0.27 | 4.02 | 6.87E-5 | Obesity-related traits |
| BLCA | cis | rs6951245 | 1 | rs77305932 | chr7:1100861 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.45 | 1.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |